Griffonia (Bandeiraea) simplicifolia Lectin (GSL I)

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Griffonia simplicifolia lectin (GSL I) is isolated from a woody climbing shrub native to Africa and purified by affinity chromatography. GSL I has a molecular weight of 114, 000 and an isoelectric point between pH 5.0 and pH 6.5. GSL I is composed of two types of subunits A and B that combine to form tetrameric structures, resulting in five isolectins. This lectin has affinity for terminal -D-galactosyl residues and terminal N-acetyl–D-galactosaminyl residues, and elutes with the sugar galactose. The A-rich lectin preferentially agglutinates blood group A erythrocytes and thus appears to be specific for -N-acetylgalactosamine residues, while the B-rich lectin preferentially agglutinates blood group B cells and is specific for -galactose residues. This lectin shows specificity for blood group B greater than blood group A1.GSL I has been reported to bind several glycoproteins including laminin. Studies show that some -D-galactosyl residues are expressed in endothelial cells of mouse tissues and provide evidence that these cells can present a highly specific surface of glycosylation pattern. See other GSL I conjugates.This product comes in lyophilized form and is stored at -20° C. Reconstitute with sterile buffer. Calcium and manganese ions are required for binding.

-20° C.

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