Myelin Oligodendrocyte Glycoprotein

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Myelin Oligodendrocyte Glycoprotein, MOG.

MOG is a transmembrane protein expressed on the surface of oligodendrocyte cell and on the outermost surface of myelin sheaths. MOG comprises about 0.1% of total CNS myelin protein. The MOG gene is a member of the immunoglobulin gene superfamily and is found within the MHC. The MOG gene is found on chromosome 6p21.3-p22. Myelin Oligodendrocyte Glycoprotein is a glycoprotein thought to be significant in the process of myelinization of nerves in the central nervous system (CNS). MOG peptide (35-55) is highly encephalitogenic and can induce strong T and B cell responses. A single injection of this peptide produces a relapsing- remitting neurologic disease with extensive plaque-like demyelination. Because of the clinical, histophathologic, and immunologic similarities with multiple sclerosis (MS), the MOG induced demyelinating encephalomyelitis may serve as a model for investigating MS.

Myelin Oligodendrocyte Glycoprotein is a single, non-glycosylated polypeptide chain containing 21 amino acids and having a molecular mass of 2582 Dalton, the molecular formula: C118H177N35O29S.

Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

The protein was lyophilized with no additives.

It is recommended to reconstitute the lyophilized MOG in sterile 18M-cm H2O not less than 100g/ml, which can then be further diluted to other aqueous solutions.

Lyophilized MOG although stable at room temperature for 3 weeks, should be stored desiccated below -18?C. Upon reconstitution MOG should be stored at 4?C between 2-7 days and for future use below-18?C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Amino Acid Composition

Bio-world products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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MOG Antibody, MOG Human

-20° C.

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