Myelin Oligodendrocyte Glycoprotein

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Synonyms
Myelin Oligodendrocyte Glycoprotein, MOG.

MOG is a transmembrane protein expressed on the surface of oligodendrocyte cell and on the outermost surface of myelin sheaths. MOG comprises about 0.1% of total CNS myelin protein. The MOG gene is a member of the immunoglobulin gene superfamily and is found within the MHC. The MOG gene is found on chromosome 6p21.3-p22. Myelin Oligodendrocyte Glycoprotein is a glycoprotein thought to be significant in the process of myelinization of nerves in the central nervous system (CNS). MOG peptide (35-55) is highly encephalitogenic and can induce strong T and B cell responses. A single injection of this peptide produces a relapsing- remitting neurologic disease with extensive plaque-like demyelination. Because of the clinical, histophathologic, and immunologic similarities with multiple sclerosis (MS), the MOG induced demyelinating encephalomyelitis may serve as a model for investigating MS.

Description
Myelin Oligodendrocyte Glycoprotein is a single, non-glycosylated polypeptide chain containing 21 amino acids and having a molecular mass of 2582 Dalton, the molecular formula: C118H177N35O29S.

Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation
The protein was lyophilized with no additives.

Solubility
It is recommended to reconstitute the lyophilized MOG in sterile 18M-cm H2O not less than 100g/ml, which can then be further diluted to other aqueous solutions.

Stability
Lyophilized MOG although stable at room temperature for 3 weeks, should be stored desiccated below -18?C. Upon reconstitution MOG should be stored at 4?C between 2-7 days and for future use below-18?C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Amino Acid Composition
H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH.

Usage
Bio-world products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Related Products
MOG Antibody, MOG Human

-20° C.

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Additional Information

Brand

Product Code

Origin

USA

BTN - HC

Size

KGS

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