Sambucus nigra (Elderberry) Lectin (SNA/EBL I) – Pure
Sambucus nigra lectin (EBL I, also known as SNA I) is an isolectin isolated from elderberry bark. This lectin has a molecular weight of 140, 000 and an isoelectric point between pH 5.4 and pH 5.8. It does not have blood group specificity.EBL I belongs to the group of type 2 ribosome-inactivating proteins and is a chimeric lectin composed of an A-chain with enzymatic activity and a B-chain with carbohydrate-binding activity. It has a unique specificity for 2, 6-linked sialic acid residues, and elutes with the sugar lactose in buffered saline or acetic acid. This lectin induces caspase-dependent apoptosis at low concentrations (nM order), leading to typical symptoms of cell death in sensitive cells. This effect depends on the carbohydrate binding of the B-chain and is independent from the catalytic activity of the A-chain. See other EBL I conjugates.This product comes in a lyophilized form and is stored at -20° C. Reconstitute with sterile buffer.