Sambucus nigra (Elderberry) Lectin (SNA/EBL II)
Sambucus nigra lectin (EBL II/SNA II) is isolated from elderberry bark. This lectin is a glycoprotein containing 7.8% carbohydrate and is not blood group specific. It is composed of two subunits and has a molecular weight of 140, 000. EBL II has a specificity for carbohydrates containing terminal N-acetylgalactosamine and galactose residues.The blood group A-active trisaccharide containing L-fucosyl group linked 1-2 to galactose is 10-fold lesser as an inhibitor than the parent oligosaccharide (GalNAc 1-3Gal), which suggests steric hindrance to binding by the -L-fucosyl group and explains the failure of the lectin to exhibit blood group A specificity.EBL II induces caspase-dependent apoptosis at low concentrations (nM) order, leading to typical symptoms of cell death in sensitive cells. This effect seems dependent on the carbohydrate binding B-chain. See other EBL II conjugates.This product comes in a lyophilized form and is stored at -20° C.